Synthesis and antimicrobial activity of 4‐aza‐5α‐sitostane and the 4‐methyl derivative | Zendy

AboulEnein Hassan Y. | Zendy; Doorenbos Norman J. | Zendy

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Synthesis and antimicrobial activity of 4‐aza‐5α‐sitostane and the 4‐methyl derivative

Author(s) -

AboulEnein Hassan Y.,

Doorenbos Norman J.

Publication year - 1974

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570110420

Subject(s) - chemistry , aluminum hydride , antimicrobial , lithium (medication) , ring (chemistry) , ketone , derivative (finance) , catalysis , medicinal chemistry , catalytic hydrogenation , hydride , organic chemistry , hydrogen , medicine , methoxide , financial economics , economics , endocrinology

Synthesis of 4‐aza‐5α‐sitostane (IX), and 4‐methyl‐4‐aza‐5α‐sitostane (XII) were accomplished through a set of reactions involving oxidative opening of ring A of α,β‐unsaturated ketone, ring closure, followed by catalytic hydrogenation and lithium aluminum hydride reduction, respectively. The antimicrobial activity for X and XII is reported.

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