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Antituberculous compounds. XXVIII. Synthesis of pyrazolopyridines
Author(s) -
Sekikawa Isao,
Nishie Jan,
TonoOka Shuichi,
Tanaka Yorie,
Kakimoto Shichiro
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100607
Subject(s) - chemistry , hydrazide , bacilli , isonicotinic acid , tubercle , derivative (finance) , alkyl , pyridazine , pyridine , stereochemistry , organic chemistry , bacteria , genetics , financial economics , economics , biology
In a previous paper it was reported that N′‐alkyl derivative of isonicotinic acid hydrazide (INH) was more active against tuberele bacilli than the acyl derivative containing the same number of carbon atoms. The authors subsequently reported that the pyrido[2, 3‐ d ]pyridazine was closely related to the acyl derivative of INH except that the terminal carbonyl group was cyclized to the pyridine nucleus, therefore these derivatives were not effective against tubercle bacilli; however, pyridopyridazine, which is similar to the alkyl derivatives of INH, will be more effective against tubercle bacilli. According to the similar expectation, some pyrazolopyridines were prepared.