Pyrrolopyridazines. II. Synthesis of the novel pyrrolo[3,2‐ c ]pyridazine ring system | Zendy

Dan Cook P. | Zendy; Castle Raymond N. | Zendy

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Pyrrolopyridazines. II. Synthesis of the novel pyrrolo[3,2‐ c ]pyridazine ring system

Author(s) -

Dan Cook P.,

Castle Raymond N.

Publication year - 1973

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570100522

Subject(s) - chemistry , pyridazine , ring (chemistry) , oxide , medicinal chemistry , sodium ethoxide , ether , diethyl ether , oxalate , stereochemistry , organic chemistry , ethanol

The first derivatives of the pyrrolo[3,2‐ c ]pyridazine ring system, ethyl pyrrolo[3,2‐ c ]pyridazine‐6‐carboxylate 2‐oxide (5) and ethyl 3‐chloro‐6‐methylpyrrolo[3,2‐ c ]pyridazine‐7‐glyoxalate 1‐oxide ( 12 ), were obtained in good yields from the cyclization of 4‐ethoxymethyl‐eneamino‐3‐methylpyridazine 1‐oxide (3) and 3‐chloro‐5‐(α‐ethoxyethylideneamino)‐6‐methylpyridazine 1‐oxide (14, R Cl, R 1 OMe), respectively, with diethyl oxalate and potassium ethoxide in ether.

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