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Spirans XXI. Synthesis of silaazaspiro[4.5]decanes and silaazaspiro[5.5]undecanes
Author(s) -
Rice Leonard M.,
Sheth Bhagvandas S.,
Wheeler James W.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100510
Subject(s) - chemistry , undecane , decane , cytotoxic t cell , stereochemistry , organic chemistry , biochemistry , in vitro
N ‐(2‐Dimethylaminopropyl)‐8,8‐dimethyl‐8‐sila‐2‐azaspiro[4.5]decane ( 1 ) and N ‐(3‐dimethyl‐aminopropyl)‐9,9‐dimethyl‐9‐sila‐3‐azaspiro[5.5]undecane ( 2 ) have been synthesized from 4,4‐dimethyl‐4‐silacyclohexanone ( 5 ). Biological evaluation of 1 and 2 indicated cytotoxic action against human cancer cells grown in tissue culture.