Spirans XX. Synthesis of 8,8‐dialkylazaspiro[4.5] decanes and 9,9‐dialkylazaspiro[5.5]undecanes | Zendy

Rice Leonard M. | Zendy; Sheth Bhagvandas S. | Zendy; Wheeler James W. | Zendy

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Spirans XX. Synthesis of 8,8‐dialkylazaspiro[4.5] decanes and 9,9‐dialkylazaspiro[5.5]undecanes

Author(s) -

Rice Leonard M.,

Sheth Bhagvandas S.,

Wheeler James W.

Publication year - 1973

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570100509

Subject(s) - undecane , decane , chemistry , stereochemistry , organic chemistry

N ‐(2‐Dimethylaminopropyl)‐8,8‐dimethyl‐2‐azaspiro[4.5]decane ( 1 ), N ‐(2‐dimethylaminopropyl)‐8,8‐diethyl‐2‐azaspiro[4.5]decane ( 2 ), N ‐(3‐dimethylaminopropyl)‐9,9‐dimethyl‐3‐azaspiro[5.5]undecane ( 3 ), and N ‐(3‐dimethylaminopropyl)‐9,9‐diethyl‐3‐azaspiro[5.5]undecane ( 4 ) have been synthesized from 4,4‐dimethylcyclohexanone ( 5 ) and 4,4‐diethylcyclohexanone ( 6 ). Biological evaluation of these amines showed significant inhibition of cancer cell growth in human cancer cells grown in tissue culture.

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