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Synthesis of 2‐aryl‐4‐phenyl‐5‐trifluoromethylimidazoles
Author(s) -
Lombardino Joseph G.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100502
Subject(s) - chemistry , trifluoromethyl , aryl , imidazole , medicinal chemistry , stereochemistry , organic chemistry , alkyl
Several 2‐aryl‐4‐phenyl‐5‐trifluoromethylimidazoles have been made from the previously unknown 1‐phenyl‐3,3,3‐trifluoro‐1,2‐propanedione monohdyrate. One analog, 4‐phenyl‐2,5‐bis(trifluoromethyl)imidazole, is quite acidic, exhibiting p K a 8.1.