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Pyrrolopyridazines. 1. Synthesis and reactivity of pyrrolo[2,3‐ d ]pyridazine 5‐oxides
Author(s) -
Dan Cook P.,
Castle Raymond N.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100422
Subject(s) - pyridazine , chemistry , reactivity (psychology) , ring (chemistry) , oxide , medicinal chemistry , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
Reaction of ethyl 4‐ethoxymethyleneamino‐3‐methoxy‐5‐pyridazinylpyruvate 1‐oxide ( 8 ) under various conditions constitutes a new approach to substituted pyrrolo[2,3‐ d ]pyridazines. The resulting substituted pyrrolo[2,3‐ d ]pyridazine 5‐oxides were allowed to react further to provide a number of new compounds in this ring system.