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Mannich‐type reactions of an isobasic isoquinoline
Author(s) -
Iiarsányi KáLmán,
Kiss Pál,
Korbonits Dezsö
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100401
Subject(s) - isoquinoline , chemistry , formaldehyde , amine gas treating , medicinal chemistry , base (topology) , ring (chemistry) , mannich reaction , organic chemistry , catalysis , mathematical analysis , mathematics
Base catalyzed reaction of 1‐cyanomethylene‐6,7‐dimethoxy‐1,2,3,4‐tetrahyroisoquinoline (I) with 2 moles of formaldehyde gave rise to the 1,3‐oxazino[4,3‐ a ]isoquinoline ring system (III). Reaction of I with a primary amine and 2 moles of formaldehyde gave pyrimido[ 6,1‐ a ]‐isoquinoline (VI).