Synthesis of 4(5)‐substituted 2‐amino‐5(4)‐hydroxyimino‐5(4) H ‐imidazoles and their transformation into the corresponding 3‐substituted 5‐amino‐1,2,4‐oxadiazoles | Zendy

Cavalleri Bruno | Zendy; Bellani Piero | Zendy; Lancini Giancarlo | Zendy

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Synthesis of 4(5)‐substituted 2‐amino‐5(4)‐hydroxyimino‐5(4) H ‐imidazoles and their transformation into the corresponding 3‐substituted 5‐amino‐1,2,4‐oxadiazoles

Author(s) -

Cavalleri Bruno,

Bellani Piero,

Lancini Giancarlo

Publication year - 1973

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570100315

Subject(s) - chemistry , acetic acid , alkyl , imidazole , amino acid , medicinal chemistry , transformation (genetics) , tautomer , nitrite , organic chemistry , biochemistry , gene , nitrate

Treatment of 4(5)‐phenyl(or alkyl)‐2‐aminoimidazoles with isoamyl nitrite in acetic acid afforded the corresponding 4(5)‐substituted 2‐amino‐5(4)‐hydroxyimino‐5(4) H ‐imidazoles which by heating in water were transformed into 3‐benzoyl(or acyl)‐5‐amino‐1,2,4‐oxadiazoles.

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