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Synthesis of 4(5)‐substituted 2‐amino‐5(4)‐hydroxyimino‐5(4) H ‐imidazoles and their transformation into the corresponding 3‐substituted 5‐amino‐1,2,4‐oxadiazoles
Author(s) -
Cavalleri Bruno,
Bellani Piero,
Lancini Giancarlo
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100315
Subject(s) - chemistry , acetic acid , alkyl , imidazole , amino acid , medicinal chemistry , transformation (genetics) , tautomer , nitrite , organic chemistry , biochemistry , gene , nitrate
Treatment of 4(5)‐phenyl(or alkyl)‐2‐aminoimidazoles with isoamyl nitrite in acetic acid afforded the corresponding 4(5)‐substituted 2‐amino‐5(4)‐hydroxyimino‐5(4) H ‐imidazoles which by heating in water were transformed into 3‐benzoyl(or acyl)‐5‐amino‐1,2,4‐oxadiazoles.