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Benzo[b] thiophene derivatives. XIX. The sulfur isosteres of psiloein and related isomers
Author(s) -
Campaigns K.,
Rogers R. B.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100304
Subject(s) - chemistry , thiophene , sulfur , stereochemistry , organic chemistry , medicinal chemistry
The sulfur analog of psilocin, 3‐(β‐dimethylaminoethyl)‐4‐hydroxybenzo[ b ]thiophene, and some O ‐methylated and N ‐demethylated isomers have been synthesized for pharmacological evaluation. Preliminary tests indicate central nervous system (CNS) activity, but weak pressor activity.