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Studies on the syntheses of analgesics. Part XXXVI . Synthesis of 1,2,3,4,5,6‐ilexahydro‐2,6‐methano‐6‐phenyl‐2 henzazocine [studies on the syntheses of heterocyclic compounds. Part D XI ]
Author(s) -
Kametani Telsuji,
Aoyama Toyohiko
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100303
Subject(s) - chemistry , diazepine , pictet–spengler reaction , hexa , stereochemistry , medicinal chemistry , ring (chemistry) , organic chemistry
An attempt to obtain 2,3,4,5,6,7‐hexahydro‐l H 2,7‐methano‐9‐methoxy‐3‐rnethyl‐7‐phenyl‐2,3‐benzodiazonine (II) by the Pictet‐Spengler reaction of 2,3,4,5,6,7‐hexahydro‐l H ‐4‐(3‐meth‐oxyphenyl)‐l‐methyl‐4‐phenyl‐1,2‐diazepine (XI) prepared through several steps from 1‐(3‐methoxyphenyl)phenylaeetonitrile (IV) resulted instead, in the formation of 1,2,3,4,5,6‐hexa‐hydro‐2,6‐methano‐8‐methoxy‐6‐phenyl‐2‐benzazocine (XIV).