Premium
Synthetic studies in the lsoxazoko[4,5‐ b ] pyrazine system
Author(s) -
Abushanab E.,
Lee D. Y.,
Goodman L.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100209
Subject(s) - pyrazine , chemistry , nitration , derivative (finance) , nitro , chloride , medicinal chemistry , phosphoryl chloride , organic chemistry , combinatorial chemistry , alkyl , financial economics , economics
The synthesis of 3‐methylisoxazolo[4,5‐ b ]pyrazine ( 5 ) and its 7‐oxide ( 6 ) is reported. Nitration of 6 furnished the 6‐nitro derivative ( 8 ) while reaction with phosphoryl chloride provided the chloro derivative ( 7 ). Efforts to functionalize the methyl group in 5 were not successful.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom