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Studies on the bromination of pyrimidine. A facile synthesis of 5‐bromopyrimidine
Author(s) -
Kress Thomas J.,
Moore Larry L.
Publication year - 1973
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570100204
Subject(s) - pyrimidine , halogenation , chemistry , hydrochloride , bromine , nitrobenzene , organic chemistry , catalysis , stereochemistry
Three methods for hromination of pyrimidine were investigated: ( a ) the bromination of pyrimidine hydrochloride in aromatic solvents, ( b ) the vapor phase bromination of pyrimidine, and ( c ) the pyrolysis of pyrimidine hydrochloride perbromide. The addition of bromine to a slurry of pyrimidine hydrochloride in nitrobenzene proved to be superior and afforded excellent yields of 5‐bromopyrimidine.