Premium
Halogenation of pyridine 1‐oxides
Author(s) -
Abramovitch R. A.,
Campbell J.,
Knaus E. E.,
Silhankova A.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090631
Subject(s) - halogenation , chemistry , pyridine , organic chemistry , oxide , medicinal chemistry
The chlorination and bromination of α‐lithiopyridine 1‐oxides has been studied. Only dihalogenated pyridine 1‐oxides are formed. In the case of bromination dipyridyl derivatives are also formed, and, indeed, predominate. Chloromercuration of the lithiopyridine 1‐oxides gave highly insoluble, unresolvable mixtures of pyridylmercury derivatives. These could be brominated readily to give mixtures of 2‐bromo‐ and 2,6‐dibromopyridine 1‐oxides.