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Synthesis in the diazasteroid group. I. A new synthesis of 8,13‐diaza‐2,3‐dimethoxygona‐1,3,5(10)triene and its mercuric acetate oxidation
Author(s) -
Matoba Katsuhide,
Isomura Kazumasa,
Nagata Masanori,
Yamazaki Takao,
Castle Raymond N.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090629
Subject(s) - chemistry , yield (engineering) , condensation , medicinal chemistry , group (periodic table) , tetrahydroisoquinoline , organic chemistry , stereochemistry , physics , materials science , metallurgy , thermodynamics
From the condensation reaction of methyl butyrolactim (I) with 1‐ethoxycarbonylmethyl‐6,7‐dimethoxy‐l,2,3,4‐tetrahydroisoquinoline (II), 8,13‐diaza‐2,3‐dimethoxygona‐l,3,5(10)trien‐12‐one (VI) and 8,13‐diaza‐2,3‐dimethoxygona‐l,3,5(10)triene (VII) were obtained in good yield. The oxidation of VI and VII with mercuric acetate was examined.