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Benzo[ b ] thiophene derivatives. XVIII. The sulfur isosteres of harmaline, harmine and related isomers
Author(s) -
Bosin T. R.,
Maickel R. P.,
Dinner A.,
Snell A.,
Campaigne E.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090614
Subject(s) - harmine , chemistry , harmaline , pyridine , thiophene , sulfur , monoamine oxidase , stereochemistry , organic chemistry , pharmacology , enzyme , medicine
The sulfur analogs of harmaline, 7‐methoxy‐3,4‐dihydro‐1‐methyl[1]benzothieno[2,3‐ c ]‐pyridine (Ib), harmine, 7‐methoxy‐1‐methyl[1]benzothieno[2,3‐ c ]pyridine (IIb), and corresponding 6‐methoxy isomers (Ic and IIc) have been synthesized for pharmacological evaluation as monoamine oxidase inhibitors.