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Quinazolincs. X. Direct formation of aminoquinazolines from hydroxyquinazolines and phenyl phosphorodiamidate
Author(s) -
Rosowsky Andre,
Papathanasopoulos Nickolas
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090608
Subject(s) - chemistry , diluent , ring (chemistry) , solvent , ether , combinatorial chemistry , medicinal chemistry , organic chemistry
Treatment of several types of liydroxyquinazoline ring systems with phenyl phosphorodiamidate resulted in direct formation of the corresponding aminoquinazolines. The reaction can be conducted either by fusion in the absence of solvent or with diphenyl ether added as a diluent. The main advantage of the method is that it obviates the usual requirement for chlori‐nation or thiation prior to animation.