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Cyclic adrenaline derivatives. Aryl‐2‐Piperidyl‐Carbinols
Author(s) -
Sankey G. H.,
Whiting K. D. E.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090516
Subject(s) - chemistry , moiety , isoprenaline , aryl , combinatorial chemistry , stereochemistry , organic chemistry , alkyl , medicine , stimulation
A synthetic route; to 3,4‐dihydroxyphenyl‐(2‐piperidyl)earbinols is described. These novel catecholamines may be regarded as derivatives of adrenaline containing a cyclic side‐chain moiety. Their biological action appears to be more selective than that of adrenaline or isoprenaline and the more active of these compounds show promise as powerful bronchodilators with minimum cardiac effect.