Synthesis of 1‐(2‐ethyl‐3‐indolyl)‐1‐(3‐pyridyl)ethylene and related ellipticine analogues | Zendy

Bergman Jan | Zendy; Carlsson RenÉ | Zendy

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Synthesis of 1‐(2‐ethyl‐3‐indolyl)‐1‐(3‐pyridyl)ethylene and related ellipticine analogues

Author(s) -

Bergman Jan,

Carlsson RenÉ

Publication year - 1972

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570090412

Subject(s) - chemistry , indole test , condensation , ethylene , medicinal chemistry , organic chemistry , condensation reaction , stereochemistry , catalysis , physics , thermodynamics

Indole, 2‐methylindole, and 3‐etliylindole have been condensed with acetyl‐ and propionylpyridine, respectively. When propionylpyridine was used as the reactant, the product always was a 1‐(pyridyl)‐1‐indoly[propylene. Condensation of 2‐substituted indoles with 3‐acetylpyridine gave similar products, whereas a similar condensation with 4‐acetylpyridine gave 1,2‐bis(3‐indolyl)‐1‐(4‐pyridyl)ethanes ( e.g . 7a ). Condensation of unsubstituted indole with 3‐or 4‐acetylpyridine respectively, gave 1,1‐bis(3‐indolyl)‐1‐(pyridyl)ethanes ( e.g . 6c ).

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