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Pyrimidine derivatives. IV . Synthesis of N 1 ‐(2‐methoxy‐4‐pyrimidyl)sulfaniiamide
Author(s) -
Okui Kiyoshi,
Ito Kiyohiko,
Kametani Tetsuji
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090410
Subject(s) - chemistry , sulfanilamide , pyrimidine , condensation , chloride , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , physics , thermodynamics
N 1 ‐(2‐Methoxy‐4‐pyrimidyl)sulfanilamide was successfully prepared through three alternative routes. Namely, the above compound was obtained by condensation of 4‐amino‐2‐methoxy‐pyrimidine (III) with p ‐acetaminobenzenesulfonyl chloride and p ‐nitrobenzenesulfonyl chloride and by direct condensation with sulfanilamide.