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Reissert compound studies. Cyclization of N ‐(ω‐chloroalkanoyl)reissert compounds
Author(s) -
Gibson Harry W.,
Chesney Dennis K.,
Popp Frank D.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090313
Subject(s) - chemistry , isoquinoline , sodium hydride , quinoline , tricyclic , stereochemistry , medicinal chemistry , organic chemistry
Treatment of 2‐(4‐chlorobutanoyl)‐ and 2‐(5‐chloropentanoyl)‐1, 2‐dihydroisoquinaldonitrile with sodium hydride gave rise to tricyclic benzoquinolizone and azepino[1,2‐α]isoquinoline derivatives. A similar reaction was observed in the quinoline series. Several reactions of 1,2,3,4‐tetrahydro‐4‐oxo‐11b H ‐benzo[α]quinolizine‐11b‐carbonitrile are reported.