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Novel 6‐(trifiuoromethyl)cytosines and 6‐(trifluoromethyl)uracils
Author(s) -
Lutz Albert W.,
Trotto Susan H.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090309
Subject(s) - chemistry , alkylation , isopropyl , trifluoromethyl , bromide , hydrolysis , aryl , alkyl , uracil , medicinal chemistry , organic chemistry , combinatorial chemistry , catalysis , dna , biochemistry
Ethyl 3‐amino‐4,4,4‐trifluorocrotonate ( 3 ) has been converted by a one step reaction with alkyl and aryl isocyanates to novel 3‐substituted‐6‐(trifluoromethyI)uracils. Also several 3‐amino‐4,4,4‐trifluorocrotonitriles ( 11a‐c ) have been cyclized to novel 6‐(trifluoromethyI)cytosines ( 13a‐c ) and then hydrolyzed to the corresponding uracils ( 4, 14b‐c ). Alkylation studies with isopropyl bromide of three 6‐(trifluoromethyl)uracils ( 1, 4, 5 ) are described.