Premium
A short synthesis of 4‐aryioxymethyl‐δ 3 ‐chromenes and 3‐(β‐aryloxy)ethylbenzofurans
Author(s) -
Majumdar K. C.,
Thyagarajan B. S.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090305
Subject(s) - chemistry , ketone , sulfuric acid , medicinal chemistry , organic chemistry , oxide
A direct and short route to the synthesis of 4‐aryloxymethyl‐δ 3 ‐chromenes and 3‐(β‐aryloxy)‐ethylbenzofurans is described. Hydration of I,4‐diaryloxy‐2‐butynes with mercuric oxide and sulfuric acid affords, instead of a ketone, the cyclization product of the ketone. In three of the diaryloxy‐butynes studied, the corresponding aryloxyethylbenzofurans are formed. In no instance could the ketone be isolated from the hydration reaction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom