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An improved synthesis of homopteroic and homofolic acids
Author(s) -
Kim YoungHo,
Grubliauskas Vytautas,
Friedman Orrie M.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090304
Subject(s) - chemistry , condensation , stereochemistry , amino acid , organic chemistry , biochemistry , thermodynamics , physics
A more practical synthesis of homopteroic and homofolic acids involving condensation of 2,4,5‐triamino‐6(1 H )pyrimidinone ( 3 ) with 1‐acetoxy‐4‐[ N ‐acetyl‐( p ‐carbethoxyphenyl)amino]‐2‐butanone ( 7 ) is described. The biological activities of homofolic ( 1‐b ) and homopteroic ( 2‐b ) acids were compared and found to be identical with the activities of these products prepared by the unambiguous route.