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Synthesis of 7,8‐dihydroxychlorpromazine and analogs
Author(s) -
Lee Fred G. H.,
Suzuki Joseph,
Dickson Donald E.,
Manian Albert A.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090234
Subject(s) - chemistry , phenothiazine , promazine , chlorpromazine , stereochemistry , spectral properties , combinatorial chemistry , organic chemistry , computational chemistry , pharmacology , medicine
7,8‐Dihydroxy derivatives of chlorpromazine, promazine, phenothiazine, and 7‐methoxy‐8‐hydroxychlorpromazine and its nor 1 analog were prepared through multi‐step syntheses. Structures were confirmed by chemical and spectroscopic evidence. The unusual nmr spectral shifts in several of these compounds are discussed.