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Preparation of some 4‐hydroxyl‐1‐methyl‐1 H ‐2,1‐benzothiazine‐3‐carboxanilide 2,2‐dioxides
Author(s) -
Lombardino Joseph G.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090221
Subject(s) - benzothiazine , chemistry , ring (chemistry) , organic chemistry , medicinal chemistry
An improved, 3‐step synthesis of 3,4‐dihydro‐1‐methyl‐1 H ‐2,1‐benzothiazin‐4‐one 2,2‐dioxide has been developed. This general method offers a more facile entrance into the 2,1‐benzothiazine 2,2‐dioxide heterocyclic system than was heretofore available. Preparation of several 3‐carbox‐anilides was accomplished by interaction of this ring system with various isocyanates. The resulting carboxanilides are moderately strong, enolic acids.