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2,1‐benzisothiazoline 2,2‐dioxide. I. Some 3‐substituted derivatives
Author(s) -
Skorcz Joseph A.,
Suh John T.
Publication year - 1972
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570090209
Subject(s) - chemistry , condensation , medicinal chemistry , organic chemistry , thermodynamics , physics
A number of 3‐mono‐ and 3,3‐disubstituted derivatives of 1‐methyl 2,1‐benzisothiazoline 2,2‐dioxide (IIa), a unique benzosultam, were synthesized. Starting materials for the condensation and aminoalkylation reactions utilized were IIa and the 3‐methyl compound IIb, which were prepared by cyclization of the 2′‐chloro‐ N ‐methylalkylsulfonanilides, Ia and b, respectively.
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