Premium
Synthesis of two new heterocyclic ring systems: Benzo[3,4] cyclohepta[1,2‐ d ]‐pyrimidines and benzo[3,4]cyclohepta[2,1‐ d ] pyrimidines
Author(s) -
Rosowsky Andre,
Chen Katherine K. N.,
Lin May,
Nadel Marilyn E.,
Amand Richard St.,
Yeager Sandra A.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080521
Subject(s) - chemistry , ring (chemistry) , pyrimidine , d 1 , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , receptor
Three 2,4‐diamino‐l(), 11‐dihydro‐9 H ‐benzo[3,4]cyclohepta[ 1,2‐ d ]pyrimidines (6a‐6c) representing the first examples of a new ring system were synthesized from 2‐benzosuberones and cyanoguanidine. Similarly, 2,4‐diamino‐6,7‐dihydro‐5 H ‐benzo[3,4]cyelohepta[2,1‐ d ]pyrimidine ( 24 ) was prepared from 1‐benzosuberone. The ultraviolet spectral properties of these compounds were examined with reference to those of the analogs in which the central ring is five‐ and six‐mernbered.