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The synthesis of some 7‐ and 7,8‐substituted 2,3,4,5‐tetrahydro‐1 H ‐3‐benzazepines
Author(s) -
Pecherer B.,
Sunbury R. C.,
Brossi A.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080519
Subject(s) - benzazepines , benzazepine , chemistry , nitration , ether , cleavage (geology) , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , geotechnical engineering , fracture (geology) , engineering
The nitration of 2,3,4,5‐tetrahydro‐1 H ‐3‐benzazepine and its 3‐methyl and 3‐acetyl derivatives yields the corresponding 7‐nitro derivatives which can be further transformed by classical procedures. The preparation of the ether cleavage products of the known 2,3,4,5‐tetrahydro‐7,8‐dimethoxy‐1 H ‐3‐benzazepine is also reported.