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Geometrical isomerism of ethyl N ‐(2‐pyridinyl)aminomethylenecyanoacetates
Author(s) -
Nishigaki Sadao,
Ichiba Misuzu,
Shinomura Kazuko,
Yoneda Fumio
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080515
Subject(s) - chemistry , cis–trans isomerism , hydrochloric acid , medicinal chemistry , stereochemistry , organic chemistry
Abstract The pure cis ‐ and trans ‐isomers of ethyl N ‐(2‐pyridinyl)aminomethylenecyanoacetates were obtained and their structure and their interconvertibility is diseussed. 4 H ‐Pyrido[1,2‐ a ]pyrimidin‐4‐one‐3‐carboxylic acids were synthesized by treatment of both cis ‐ and trans ‐isomers with hydrochloric acid.