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Halogenated ketenes. XXIII. 2‐Oxetanones
Author(s) -
Brady William T.,
Patel Arvind D.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080510
Subject(s) - chemistry , ketene , cycloaddition , ketone , zinc , halogenation , carbonyl group , chloride , medicinal chemistry , organic chemistry , catalysis
The cycloaddition of dichloroketene with several simple ketones to produce 2‐oxetanones is described. The ketene is generated in situ by the zine dehalogenation method and the zinc/zinc chloride activates the carbonyl group of the ketone. The cycloaddition of methylchloro‐ and methylbromoketenes with some activated carbonyl compounds is also deseribed.