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Synthesis of furo[2,3‐ b ]pyridine
Author(s) -
Mcfarland J. W.,
Wollerman R. P.,
Sadler W. C.,
Coleman G. N.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080509
Subject(s) - chemistry , decarboxylation , deamination , pyridine , hydrolysis , medicinal chemistry , organic chemistry , stereochemistry , enzyme , catalysis
Two routes were employed to synthesize unsubstituted furo[2,3‐ b ]pyridine (IV). The first method started with ethyl 5‐aminofuro[2,3‐ b ] pyridine‐2‐carboxylate (1) and involved successive deamination, hydrolysis, and decarboxylation. The second method began with 5‐nitrofuro[2,3‐ b ]‐pyridine‐2‐carboxylic acid (V) and consisted of successive decarboxylation, reduction, and deamination reactions.
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