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The preparation of 3‐chlorobenzo[ b ] thiophene derivatives from cinnamie acids
Author(s) -
Wright W. B.,
Brabander H. J.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080504
Subject(s) - chemistry , thionyl chloride , thiophene , pyridine , chloride , organic chemistry , cinnamic acid , acyl chloride , medicinal chemistry
The reaction of cinnamic acid derivatives with thionyl chloride and pyridine is a general procedure for the preparation of derivatives of 3‐chlorobenzo[ b ] thiophene‐2‐carbonyl chloride from readily accessible starting materials. These compounds are easily converted to the corresponding acids, esters and amines.
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