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An investigation of the minimal structural conditions lor the dirnroth‐type rearrangement in the polyazaindolizine series
Author(s) -
Guerret Patrick,
Jacquier Robert,
Maury Georges
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080419
Subject(s) - chemistry , diazine , steric effects , series (stratigraphy) , pyrimidine , aqueous solution , medicinal chemistry , stereochemistry , organic chemistry , paleontology , biology
In the imidazo[1,2]diazine series, only the imidazo[1,2‐ a ]‐ and [1,2‐ c ] pyrimidine systems were found to undergo a Dimroth‐type rearrangement under basic aqueous conditions. The electronic and steric factors influencing the rearrangement rates of methyl substituted imidazo‐[1,2‐ a ] pyrimidines are discussed.
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