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1,3,5‐Trisubstituted hexahy drotriazines as mannich reagents. I. Preparation of secondary aminomethyl sulfide hydrochlorides
Author(s) -
Reynolds Delbert D.,
Cossar Bernard C.
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080412
Subject(s) - chemistry , anhydrous , reagent , mannich reaction , sulfide , hydrogen chloride , hydrogen sulfide , chloride , organic chemistry , combinatorial chemistry , sulfur , catalysis
1,3,5‐Trisubstituted hexahy drotriazines react with hydrogen chloride in the presence of anhydrous solvents to form useful intermediates for the introduction of the RNHCH 2 ‐ group into compounds which undergo the Mannich reaction. The effectiveness of the new aminomethyl‐ating agent has been demonstrated by the preparation of secondary aminomethyl sulfide hydro‐chlorides.