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Synthesis of 10‐deazapteroic and 11‐deazahomopteroic acids
Author(s) -
Degraw Joseph I.,
Tsakotellis Panayotis,
Kisliuk Roy L.,
Gaumont Yvette
Publication year - 1971
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570080119
Subject(s) - plasmodium gallinaceum , chemistry , plasmodium berghei , pteridine , plasmodium (life cycle) , antimalarial agent , stereochemistry , avian malaria , biochemistry , plasmodium falciparum , malaria , gametocyte , parasite hosting , biology , immunology , world wide web , computer science , enzyme
The syntheses of 10‐deazapteroic and 11‐deazahomopteroic acids are described. These compounds along with their simple 6‐phenylalkylpteridinol relatives were found to be inactive as antimalarial agents against the Plasmodium berghei or Plasmodium gallinaceum strains. 10‐Deazapteroie acid was a potent growth inhibitor of Streptococcus faecium both in the pteridine and tetrahydropteridine forms.