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5 H ‐Thiazolo [3,2‐ b ]‐ and 2 H ‐Thiazolo [2,3‐ c ]‐as‐triazines
Author(s) -
Trepanier Donald L.,
Krieger Paul E.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070601
Subject(s) - chemistry , ethyl bromoacetate , triazine , medicinal chemistry , d 1 , condensation , stereochemistry , organic chemistry , receptor , biochemistry , physics , thermodynamics
Derivatives of the 5 H ‐thiazolo[3,2‐ b ]‐ and 2 H ‐thiazolo[2,3‐ c ]‐as‐triazine systems were synthesized via condensation of tetrahydro‐I‐methyl‐ as ‐triazine‐3(2 H )‐thione with ethylene dibromide and ethyl bromoacetate, respectively. An hypothesis is given for the formation of the [3,2‐ b ] system in one of these reactions and the [2,3‐ c ] system in the other. Structure proof was accomplished by an unequivocal synthesis of one of the [2,3‐ c ] derivatives.