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Oxidative coupling of 2 H ‐1,4‐Thiazine derivatives
Author(s) -
Sica D.,
Santacroce C.,
Prota G.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070522
Subject(s) - chemistry , oxidizing agent , oxidative phosphorylation , oxidative coupling of methane , coupling (piping) , thiazine , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , biochemistry , metallurgy , methane , materials science
When treated with oxidizing agents, 3,5‐disubstituted 2 H ‐1,4‐thiazines undergo oxidative coupling at the 2‐position yielding 2,2′‐bithiazines. Under similar conditions 3‐substituted 2 H ‐1,4‐benzothiazines behave similarly to give the corresponding 2,2′‐dehydrodimers. Evidence is presented that the oxidative coupling of all compounds examined proceeds preferentially to give the meso ‐isomers.