Premium
Synthesis of pyridyl‐ and quinolyl‐substituted 2‐aminothiazoles
Author(s) -
Taurins Alfred,
Blaga Aurel
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070521
Subject(s) - thiourea , chemistry , thiazole , halogen , condensation , ring (chemistry) , medicinal chemistry , stereochemistry , organic chemistry , alkyl , physics , thermodynamics
Five 2‐amino‐4‐(x‐pyridyl)‐ and 2‐amino‐4‐(x‐quinolyl)thiazoles have been synthesized by the condensation of thiourea with bromoacetylpyridines and ‐quinolines. The reaction of pyridyl pyridylmethyl ketones with thiourea and halogens produced four 2‐aminothiazoles possessing pyridyl substituents in 4‐ and 5‐positions on the thiazole ring. Treatment of N ‐(3‐pyridyl)‐ and N ‐(3‐quinoiyl)thiourea with α‐bromoketones gave seven new 2‐(3‐pyridyl)amino‐ and 2‐(3‐quinolyl)aminothiazoles. The ultraviolet spectra of the pyridyl‐ and quinolyl‐ substituted 2‐aminothiazoles were recorded.