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Investigation of some tetrazole derivatives of 1,8‐naphthyridines
Author(s) -
Carboni S.,
Da Settimo A.,
Ferrarini P. L.,
Ciantelli P. L.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070506
Subject(s) - tetrazole , chemistry , ring (chemistry) , solid state , stereochemistry , nucleus , organic chemistry , biology , microbiology and biotechnology
Several tetrazole derivatives have been prepared from 7‐amino‐2‐hydroxy‐3‐phenyl‐1,8‐naphthyridine (Id). Evidence is presented to demonstrate that the tetrazole ring structure is the dominant species in the solid state and in alkaline solution while the open‐chain azido form dominates in acidic solution. In addition it has been shown that the presence of a phenyl group in a position adjacent to the tetrazole nucleus apparently stabilizes the tetrazole ring.