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The synthesis of ribonucleotide‐5′‐(5‐Iodoindol‐3‐ol) and (4‐methylcoumarin‐7‐ol) esters for the histochemical demonstration of nucleases
Author(s) -
March Louis C.,
Tsou K. C.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070422
Subject(s) - chemistry , ribonucleotide , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry , nucleotide , gene
The syntheses of ribonucleotide‐5′ monoesters with 5‐iodoindol‐3‐ol and 5′‐uridylic acid and 5′‐adenylic acid monoesters with 4‐methylcoumarin‐7‐ol has been accomplished by the reaction of phosphorodichloridates with various 2′,3′‐ O ‐isopropylidene ribonucleosides, followed by hydrolysis and anion exchange chromatography.