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Synthesis of 2– and 4‐amino‐1,5‐naphthyridines
Author(s) -
Brown Ellis V.,
Plasz Andrew C.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070319
Subject(s) - chemistry , liquid ammonia , amide , potassium , amino acid , ammonia , nmr spectra database , product (mathematics) , stereochemistry , spectral line , combinatorial chemistry , medicinal chemistry , organic chemistry , biochemistry , physics , geometry , mathematics , astronomy
The structure of the product obtained from the reaction of potassium amide in liquid ammonia on 1,5‐naphthyridine has been identified as 4‐amino‐1,5‐naphthyridine by comparison with a known sample. The 2‐amino isomer was not detected in the mixture. The NMR spectra for 2‐and 4‐amino‐1,5‐naphthyridine along with the corresponding chloroisomers are described.