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Reactions of some 4‐methylene‐4 H ‐pyran derivatives with primary and secondary amines
Author(s) -
Vanallan J. A.,
Reynolds G. A.,
Petropoulos C. C.,
Maier D. P.
Publication year - 1970
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570070306
Subject(s) - chemistry , primary (astronomy) , pyran , methylene , organic chemistry , dihydropyridine , medicinal chemistry , calcium , physics , astronomy
4‐Dicyanomethylene‐4 H ‐pyrans react with secondary amines to give 2‐aminopyridine and 2‐pyridone derivatives which, in turn, have been used to prepare copyrine derivatives. These pyrans and primary amines gave copyrine and iminopyridone derivatives in addition to the dicyanomethylene‐1,4‐dihydropyridines, which had been reported previously. Reaction of cyanocarbamoylmethylene‐4 H ‐pyrans with secondary amines gave 2‐pyrones, and with primary amines, gave copyrines and 1,4‐dihydropyridine derivatives.