Synthesis of 10‐deazariboflavin and related 2,4‐Dioxopyrimido[4,5‐ b ]quinolines | Zendy

O'Brien Darrcll E. | Zendy; Weinslock Louis T. | Zendy; Cheng C. C. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis of 10‐deazariboflavin and related 2,4‐Dioxopyrimido[4,5‐ b ]quinolines

Author(s) -

O'Brien Darrcll E.,

Weinslock Louis T.,

Cheng C. C.

Publication year - 1970

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570070114

Subject(s) - chemistry , barbituric acid , anhydrous , quinoline , condensation , hydrazine (antidepressant) , sodium carbonate , potassium carbonate , medicinal chemistry , organic chemistry , hydrate , sodium , chromatography , physics , thermodynamics

Condensation of substituted anthranilaldehydes with barbituric acid results in the formation of 2,4‐dioxopyrimido[4,5‐ b ]quinolines. Using this general synthetic approach, 7,8‐dimethyl‐2,4‐dioxo‐10‐ribityl‐2,3,4,10‐tetrahydropyrimido[4,5‐ b ]quinoline (10‐deazariboflavin) was prepared by the condensation of barbituric acid with 4,5‐dimethyl‐ N ‐ribitylanthranilaldehyde. The latter was obtained in situ by the treatment of 1‐[4,5‐dimethyl‐ N ‐(ribityl)anthraniloyl]‐2‐( p ‐toluenesulfonyl)hydrazine, prepared from 4,5‐dimethylanthranilic acid with anhydrous sodium carbonate.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research