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Nucleoside analogs. I. A synthesis of 1,3‐dihydroxy‐2‐(6‐substituted‐9‐purinyl)cyclohexane
Author(s) -
Suami Tetsuo,
Sato Yutaka,
Fukai Yasushi,
Sakota Yukio
Publication year - 1969
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570060512
Subject(s) - chemistry , pyrimidine , cyclohexane , xanthomonas oryzae , cyclohexanes , nucleoside , stereochemistry , nucleophilic substitution , bacteria , nucleophile , organic chemistry , biochemistry , catalysis , gene , genetics , biology
Biologically active 1,3‐dihydroxy‐2‐(6‐substituted‐9‐purinyl)cyclohexanes (VI‐X) were prepared by a reaction between trans ‐2‐amino‐1,3‐cyclohexanediol (I) and 4,6‐dichloro‐5‐amino‐pyrimidine (II), followed by cyclization and nucleophilic substitution. Compounds VI and VII showed a weak inhibitory effect against Xanthomonas oryzae , a pathogenic bacteria of leaf blight of rice plant.