Nucleoside analogs. I. A synthesis of 1,3‐dihydroxy‐2‐(6‐substituted‐9‐purinyl)cyclohexane | Zendy

Suami Tetsuo | Zendy; Sato Yutaka | Zendy; Fukai Yasushi | Zendy; Sakota Yukio | Zendy

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Nucleoside analogs. I. A synthesis of 1,3‐dihydroxy‐2‐(6‐substituted‐9‐purinyl)cyclohexane

Author(s) -

Suami Tetsuo,

Sato Yutaka,

Fukai Yasushi,

Sakota Yukio

Publication year - 1969

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570060512

Subject(s) - chemistry , pyrimidine , cyclohexane , xanthomonas oryzae , cyclohexanes , nucleoside , stereochemistry , nucleophilic substitution , bacteria , nucleophile , organic chemistry , biochemistry , catalysis , gene , genetics , biology

Biologically active 1,3‐dihydroxy‐2‐(6‐substituted‐9‐purinyl)cyclohexanes (VI‐X) were prepared by a reaction between trans ‐2‐amino‐1,3‐cyclohexanediol (I) and 4,6‐dichloro‐5‐amino‐pyrimidine (II), followed by cyclization and nucleophilic substitution. Compounds VI and VII showed a weak inhibitory effect against Xanthomonas oryzae , a pathogenic bacteria of leaf blight of rice plant.

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