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Alcoholation of the trifluoromethyl group. I. Ortho esters derived from 1‐ and 3‐trifluoromethylphenothiazines
Author(s) -
Saggiomo Andrew J.,
Asai Masaru,
Schwartz Pauline M.
Publication year - 1969
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570060506
Subject(s) - chemistry , trifluoromethyl , hydrolysis , phenothiazine , group (periodic table) , organic chemistry , medicinal chemistry , alkyl , medicine , pharmacology
The preparation of 1‐trifluoromethylphenothiazine is reported. Methanolic basic hydrolysis of 1‐ and 3‐trifluoromethylphenothiazines to the corresponding ortho esters of phenothiazine‐carboxylic acids is described.