Premium
Compounds in the pyrrolo[3,4‐ d ]pyrimidine series. derivatives with 6‐aryl substituents
Author(s) -
Southwick Philip L.,
Madhav R.,
Fitzgerald James A.
Publication year - 1969
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570060410
Subject(s) - chemistry , aryl , pyrimidine , substituent , pyrrolidinones , stereochemistry , organic chemistry , alkyl
Methods are described for the synthesis of 6,7‐dihydro‐5 H ‐pyrrolo[3,4‐ d ]pyrimidines having an aryl substituent in the 6‐position. 4‐Hydroxy‐, 4‐amino, 2‐amino‐4‐hydroxy and 2,4‐diamino derivatives were obtained. The synthetic route involved the preparation of 1‐aryl‐4‐cyano‐ or 4‐carboalkoxy‐3‐pyrrolidinones and 1‐aryl‐4‐cyano‐ or 4‐carboalkoxy‐3‐amino‐3‐pyrrolines as key intermediates.