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A new synthesis of anthyridine derivatives
Author(s) -
Carboni S.,
Da Settimo A.,
Segnini D.
Publication year - 1969
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570060315
Subject(s) - chemistry , sulfuric acid , ullmann reaction , amino acid , organic chemistry , catalysis , biochemistry
An Ullmann reaction between 2‐bromonicotinic acid and 2,6‐diaminopyridine gave 6 ‐amino‐2,2 ‐dipyridylamino‐3‐carboxylic acid (V). The latter was converted into 7‐amino‐5 H ‐dipyrido‐[1,2‐ a :2,3 ‐d]pyrimidin‐ 5‐one (VII) by heating with polyphosphoric acid and into 2‐amino‐5,10 H ‐anthyridin‐5‐one (VIII) by heating with concentrated sulfuric acid. Structure proofs of VII and VIII are given and some derivatives of VIII are described.