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Syntheses of benzomorphan and related compounds. Part 1. Synthesis of N ‐substituted‐l,2,3,4,5,6‐hexahydro‐8‐hydroxy‐2,6‐methano‐6,11‐dimethyl‐3‐benzazocine [studies on the syntheses of heterocyclic compounds. Part CCLXXXII ]
Author(s) -
Kametani T.,
Kigasawa K.,
Hüragi M.,
Hayasaka T.,
Wagatsuma N.,
Wakisaka K.
Publication year - 1969
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570060108
Subject(s) - chemistry , pentazocine , ammonium , catalysis , medicinal chemistry , stereochemistry , organic chemistry , analgesic , medicine , pharmacology
A modified synthesis of pentazocine, l,2,3,4,5,6‐hexahydro‐8‐hydroxy‐2,6‐methano‐6, H‐dimethyl‐3‐(3‐methyl‐2‐butenyl)‐3‐benzazocine (III), has been achieved and catalytic hydro‐genation has been found to be effective for the debenzylation of quaternary ammonium salts.