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A facile synthesis of 5‐substituted 1‐methyluracils and cytosine
Author(s) -
Sakai Ted. T.,
Pogolotti Alfonso L.,
Santi Daniel V.
Publication year - 1968
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570050618
Subject(s) - chemistry , substituent , cytosine , alkylation , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , dna , biochemistry
A facile, general synthesis for a number of 5‐substituted‐1‐methyluracils and cytosine which is suitable for the preparation of micro‐quantities is reported. In contrast to other methods, the 5‐substituent plays no role in determining the position of alkylation. 1‐Methyl‐5‐hydroxymethyluracil and 1‐methyl‐5‐formyluracil have also been synthesized by an alternate route.